Postdoctoral Opportunities at Fels Cancer Institute for Personalized Medicine
Dr. Jonathan Soboloff
Fels Institute (Temple University, Philadelphia, PA) has several openings for a postdoctoral position in Cancer related fields. PIs with openings include:
- Dr. Jonathan Soboloff (Modulation of Ca2+ signaling by STIM1)
I am interested in recruiting a new postdoctoral fellow to study numerous aspects of STIM-dependent Ca2+ signaling. The ideal candidate will have a recent PhD, at least 1 first author publication in a mid- to high-impact journal. Our interests include fundamental mechanisms regulating the generation of Ca2+ signals and their relevance to multiple aspects of immunology, cancer and bone physiology. However, as this lab has just received new funding to investigate T cell activation, the new lab member would be expected to work primarily in this area. Research techniques used in the lab include advanced microscopy approaches, Western analysis, ChIP, qPCR and general molecular biology.
The position is fulltime, with the expectation that the fellow will be independently motivated. As a postdoctoral fellow, the primary duty will be to complete scientific experiments towards the preparation of published works, although I will also support career development as appropriate and needed. The ideal candidate will keep up with relevant literature, contribute to scientific writing and present our research at international conferences with my full support.
Finally, as a senior lab member, I anticipate that the fellow will contribute to the training of junior lab members. When significant, these contributions will be recognized with authorship on publications.
US citizens/green card holders will have opportunities for external funding and will receive special consideration.
Please submit application electronically with curriculum vitae, a cover letter, and the names/phone numbers/emails of three people who can provide letters of reference to: Dr. Jonathan Soboloff, Fels Cancer Institute for Personalized Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA. Email: soboloff@temple.edu.
Dr. Tomasz Skorski
Postdoctoral positions supported by NIH/NCI grants are immediately available in the laboratory of Dr. Tomasz Skorski, the Director of Fels Cancer Institute for Personalized Medicine at Temple University School of Medicine, Philadelphia. The research is focused on: (1) determination the mechanistic aspects of how mutations driving leukemias modulate DNA damage response, (2) identification of mutation patterns in leukemias, which determine the sensitivity of malignant cells to specific DNA repair inhibitors, and (3) testing new drugs targeting DNA damage response in single cells/clones. Our overall goal is to develop biomarkers that predict tumor response to novel DNA repair inhibitors combined with standard DNA damaging agents and to understand molecular mechanisms. Research involves molecular biology of DNA repair, testing novel drugs, mouse models of cancer, bioinformatics, and extensive mammalian tissue culture. Candidates must be enthusiastic to commit necessary effort required to develop a successful and highly productive research career. Candidates must be residing in the U.S.
Candidates interested in the position should send curriculum vitae, a brief description of research experience, and names of three references to Dr. Tomasz Skorski (Email: tskorski@temple.edu).
Dr. Sergey Karakashev
Postdoctoral positions are available in the laboratory of Dr. Sergey Karakashev. The Karakashev lab investigates the role of epigenetic regulation in ovarian cancer progression with the emphasis on the development of novel therapeutic approaches.
Ongoing research projects:
1. To study the role of epigenetic factor CARM1 in ovarian cancer. And to develop novel therapeutic approaches by targeting CARM1-expressing ovarian cancers with HSP70 inhibitors.
2. To investigate the role of epigenetic factor KDM5A in regulation of immune surveillance in ovarian cancer.
3. To identify novel epigenetic factors regulating antitumor-immune response that could be targeted by epigenetic therapies.
The Karakashev lab is NIH/NCI funded and works in collaboration with several ovarian cancer groups. For more details on research and a list of publications visit: https://pubmed.ncbi.nlm.nih.gov/?term=sergey+karakashev
Candidates should have a PhD (or equivalent) degree or be close to obtaining their doctoral degree and must have at least one first author publication. Required research skills include standard molecular and cellular biology techniques.
Applicants should send their CV via email to Dr. Sergey Karakashev. A CV should include a list of publications, manuscripts in preparation, and technical skills; names and contact information for at least 3 references.
Email: Sergey.Karakashev@temple.edu
Dr. Jayashri Ghosh
The Ghosh laboratory at the Fels Cancer Institute for Personalized Medicine, Temple University is looking for a postdoctoral fellow. The research in the laboratory is focused on investigating epigenetic changes involved in colorectal cancer (CRC) and assisted reproductive technology (ART) through epigenome-wide (DNA methylation) studies. In CRC, the major focus is on Disparity research as CRC incidence and mortality rates are disproportionately higher in Black/African American population.
The ideal candidate will be highly motivated with experience in analyzing large datasets in addition to standard molecular biology techniques. The candidate should have the ability to work independently as well as in a team. Considerable opportunities will be available for professional development.
Required applicant qualifications:
1. A PhD or equivalent degree.
2. Ability to perform molecular biology techniques
3. Experience with data analysis. Knowledge of programming languages like Python or R is a plus.
TO APPLY
Email a CV, cover letter that states research interest(s) and goals, and the name of at least three references to jayashri.ghosh@temple.edu. Qualified candidates will then be invited for a preliminary zoom interview.